Prediction of
the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs)
on protein stability starting from protein sequence using protein language model embeddings.
DDGEmb support both single-point and multi-point variations in input.
Please, use the form below to submit
a valid protein sequence in FASTA format along with the list of variations
for which you want to predict the ΔΔG.
See the Help page for more details.
How to cite DDGemb:
Castrense Savojardo, Matteo Manfredi, Pier Luigi Martelli, Rita Casadio (2025)
DDGemb: predicting protein stability change upon single- and multi-point variations
with embeddings and deep learning, Bioinformatics, 41(1), btaf019.
Bioinformatics
PubMed