Prediction of the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein sequence using protein language model embeddings. DDGEmb support both single-point and multi-point variations in input. Please, use the form below to submit a valid protein sequence in FASTA format along with the list of variations for which you want to predict the ΔΔG.

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How to cite DDGemb:

Castrense Savojardo, Matteo Manfredi, Pier Luigi Martelli, Rita Casadio (2025) DDGemb: predicting protein stability change upon single- and multi-point variations with embeddings and deep learning, Bioinformatics, 41(1), btaf019.
Bioinformatics PubMed